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pentobarbital will reduce the extent or impact of guanfacine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Solid or average CYP3A4 inducers significantly cut down guanfacine plasma concentrations and elimination 50 %-daily life.pentobarbital will lessen the extent or influence of eletriptan by